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PLANT BIOPREPARATIONS FOR PHARMACEUTICAL PRODUCTION

DEVELOPMENT OF TECHNOLOGY FOR OBTAINING CANNABINOIDS FROM HEMP WITH A LOW THC CONTENTS AS REMEDIES SUPPORTING CANCER TREATMENT

Development of technology for obtaining cannabinoids from hemp with a low THC contents as remedies supporting cancer treatment. Acronym ONKOKAN. The project implemented as part of the INNOMED Program of the National Center for Research and Development from the funds of the Innovative Economy Operational Program under the European Regional Development Fund (2014-2018). Project coordinator: Prof. dr hab. Ryszard Słomski.

The project related to the medical biotechnology involve the development of cannabinoid extract with reduced psychoactive component (THC), which due to its high content of cannabidiol (CBD) will provide analgesic properties, and at the same time reduce the risk of addiction and overdose. Commercially available preparations are characterized by a high content of THC, since they are directed to other types of pain than the neuropathic pain. The project will result in an innovative approach to produce cannabinoid preparation of low-THC content for the treatment of pain in cancer patients. Project stages include: selection and standardization of plant material for the extract preparation according to the pharmaceutical procedures; evaluation of the efficacy and mechanism of action of extracts in an animal and cellular models; evaluation of DNA polymorphism and expression of human genes involved in the metabolism of cannabinoids and development of the mucoadvesive formulations of extracts.