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TRANSGENIC ANIMALS FOR XENOTRANSPLANTATION

DEVELOPMENT OF AN INNOVATIVE TECHNOLOGY USING TRANSGENIC PORCINE TISSUES FOR BIOMEDICAL PURPOSES

Development of an innovative technology using transgenic porcine tissues for biomedical purposes Acronym MEDPIG. The project implemented as part of the INNOMED Program of the National Center for Research and Development from the funds of the Innovative Economy Operational Program under the European Regional Development Fund (2014-2018). Project coordinator: Prof. dr hab. Ryszard Słomski.

The aim of project is to develop innovative technologies for biomedicine based on tissues of transgenic pigs. The project is an alternative to stem cells and artificial organs. The project is scheduled for eight major tasks: 1) Development of pigs breeding system and obtaining of transgenic pigs tissues; 2) Development of reproduction biotechnology of multitransgenic swine; 3) Development and characterization of gene constructs for transgenesis; 4) Multiparameter characterization of transgenic animals; 5) Development of human vascular diseases treatment; 6) Development of technology for innovative heart valve prototype bioprosthesis, 7) Preparation of biological dressing for treatment of burns and chronic wounds, 8) Quality control of cohesion of performed tasks and control of stability of transgenesis. Transgenic pigs tissues like skin or valves and vessels can be used for treatment of oncologic patients. The project involves the development and implementation of innovative technologies and the strengthening of cooperation between science and industry.

References: Hryhorowicz M, Zeyland J, Słomski R, Lipiński D, 2017,Genetically Modified Pigs as Organ Donors for Xenotransplantation, Mol Biotechnol, 59, 435-444. Zeyland J, Lipiński D, Słomski R, 2015, The current state of xenotransplantation, J Appl Genet, 56, 211-218.